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One major limitation is the incomplete knowledge of the metabolic pathways and transformations that polyphenols undergo after ingestion, particularly due to interactions with the gut microbiome and the formation of diverse metabolites whose biological activities are not well characterized ( There is also a critical need for well-designed long-term safety studies addressing the potential side effects of chronic polyphenol supplementation, as current data are mainly limited to short-term animal experiments or isolated compounds, and results from these do not always translate directly to humans ( Clinical research on polyphenol bioavailability is advancing, but large-scale intervention trials remain scarce

These pathological changes compromise airway integrity and immune regulation, thereby heightening the susceptibility to asthma in older adults

This estimate is conservative because the trailers are usually not stuffed with cigarettes, since they need to be hidden among other goods to thwart possible detection at weigh stations or during direct inspections

Warning: Just because traditional tobacco is less processed does not mean it is safe